Sex-stratified RNA-seq analysis reveals traumatic brain injury-induced transcriptional changes in the female hippocampus conducive to dementia.

Co-expression of TBI-associated DEGs and module-trait relationships To identify gene modules of highly connected genes, we subjected all nominally significant TBI-associated DEGs ( p -value < 0.05 and |log2 fold change| > 0.5) to a weighted gene co-expression network analysis (WGCNA), stratified by brain region and sex.

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Additionally, the red module ( Supplementary Table 8 ) displayed a positive correlation that approached significance (r = 0.4, p = 0.09) with strong adjacency (>0.7) to both the black and green modules and was therefore included in downstream analyses.

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