Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2.

ChemMedChem · 2022 · PMC9827907 · PMID 36129427

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nominally significantno p-value reported

Clone D3 showed a nominally significant IC 50 increase that was 1.6‐fold higher than parental Dd2‐B2.

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showed a trendno p-value reported

E5 showed a trend towards a lower IC 50 compared with D2‐B2, although this did not attain significance (p=0.07).

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