Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold.

Responses to noxious or innocuous mechanical stimulation showed a trend toward reduced sensitivity that did not reach statistical significance (pin-prick response score: 89% ± 3% versus 83% ± 3%, for control versus hM3Dq mice, p = 0.21 unpaired t test; von Frey test threshold: 3.9 ± 0.2 g versus 4.2 ± 0.2 g, p = 0.22; brush test response score: 91% ± 3% versus 81% ± 5%, p = 0.13).

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