TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy.

Furthermore, increases in CD8 + T cells, B cells, macrophages, and M2-like macrophages showed an inverse correlation with increased BLI signal, although the correlations did not reach statistical significance ( r = −0.3; p > 0.3, r = −0.3; p > 0.2, r = −0.06; p > 0.9; r = −0.4; p > 0.8, respectively) (Fig. 6a, b ).

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However, tumor samples taken from treated mice showed a trend toward increased variability in the number of myeloid cells (Supplementary Fig. 9 ; myeloid cells panel, treated controls).

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