Detection of antibodies against the huntingtin protein in human plasma.

However, it should be noted that a strong trend towards an increase was observed for Ataxin3 with an expanded polyQ stretch, which could indicate that at least some of the antibodies measured in patients may bind directly to the polyQ stretch.

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The idea that the expanded CAG repeat is important for detection of the full-length protein is further supported by the Ataxin 3 data which showed a trend towards an increase in severe manifest patients that mirrored the results from the full-length mHTT protein (Supplementary Fig. 2).

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