Polymorphisms in <i>ACE1</i>, <i>TMPRSS2</i>, <i>IFIH1</i>, <i>IFNAR2</i>, and <i>TYK2</i> Genes Are Associated with Worse Clinical Outcomes in COVID-19.

The A/A genotype of the rs2304256/ TYK2 polymorphism showed a trend towards increased risk of death in the recessive model (OR = 2.574, 95% CI 0.882–7.513, p = 0.084, after adjustment for covariables; Table 5 ).

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Although the associations of the rs12329760/ TMPRSS2 T allele and rs2304256/ TYK2 A/A genotype with death by COVID-19 did not reach statistical significance, interaction analysis between the IFIH1 , TMPRSS2 , and TYK2 polymorphisms showed that the presence of four or more minor alleles was significantly associated with risk of death compared to 3 or fewer minor alleles (OR = 2.622, 95% CI 1.026–6.704, p = 0.044, after adjustment for age and ethnicity; Table 5 ).

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