Are Alzheimer's and coronary artery diseases genetically related to longevity?

Front Psychiatry · 2022 · PMC9859055 · PMID 36684006

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

nominally significantp = 3.3e-07actually significant

( 23 ) and another two SNPs were nominally significant including rs11556924 ( p = 3.3e-07, locus 10) and rs2980853 ( p = 3.5e-05, locus 11). 3.2.3.

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approached significanceno p-value reported

FCHO1 is involved in endocytosis via clathrin coated endocytic vesicle pathways ( 49 ) binds APP and its missense mutation NM_001161357.1 :c.557G > A (rs147599881) approached significance in the cerebrospinal fluid (CSF) biomarker data in a recent analysis of AD-affected cousin pairs selected from high-risk pedigrees ( 50 ).

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