Natural history of familial cerebral cavernous malformation syndrome in children: a multicenter cohort study.

In our cohort, although the total number of CCM, posterior fossa CCM, and brainstem CCM was indeed higher in patients with CCM3 variants, differences did not reach statistical significance.

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The symptomatic hemorrhagic presentation also showed a trend towards an increased risk for subsequent symptomatic hemorrhagic events when compared to other forms of presentation in both univariable and multivariable analysis, although without reaching statistical significance (adjusted HR = 4.33 and HR = 4.35, P = 0.008 and 0.08, respectively) (Table 5 ).

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