Among the geriatric subjects with a poor response to vaccination (None-responders), we found that the Tryptophan Metabolism pathway showed a trend of enrichment in several closely related Kynurenine metabolites.
3
—
—
The sentences
In contrast, the purines Guanine and Hypoxanthine showed highly significant differences with respect to the High- and None-responders over time (Two-way ANOVA—row factor: days post-vaccination, column factor: responder status).
While it only approached significance in its correlation with the seroconversion score, Acetyl-Leucine showed one of the steepest slopes at 0.033, indicating that, overall, the D3 urinary metabolite levels are only weakly predictive of the ultimate seroconversion (measured at D28).