T Cell Receptor Sequences Amplified during Severe COVID-19 and Multisystem Inflammatory Syndrome in Children Mimic SARS-CoV-2, Its Bacterial Co-Infections and Host Autoantigens.

Increases were also observed in the mimicry of other proteins that did not reach statistical significance in this study, such as cardiomyopathy-associated proteins and thrombospondin, which may indicate that subsets of the COVID-19 group experienced autoimmunity related to these targets.

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The MIS-C TCRs also demonstrated significant, or near-significant, increases in similarities to antigens of herpes viruses 1 and 2 and parainfluenza virus with a near-significant decrease in similarities to reoviruses.

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