Optimizing the Preparation of Silk Fibroin Nanoparticles and Their Loading with Polyphenols: Towards a More Efficient Anti-Inflammatory Effect on Macrophages.

Furthermore, although the production of this cytokine following LPS treatment showed a rising trend, it did not reach statistical significance ( Figure 8 c,d).

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Nonetheless, all treatments (free and loaded compounds) showed a trend of getting TNF-α concentrations down to basal levels, and a further mild but not significant decrease in TNF-α was observed between LPS alone and LPS plus SFN-RES or free RES-treated cells ( Figure 8 c,d).

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