Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer's Disease Aetiopathogenesis in Men.

The effect size increased when we calculated the model exclusively using conversion to AD but did not reach statistical significance (HR = 2.05, p = 0.19). mLOY calls also showed similar but smaller non-significant positive effects for conversion to dementia (HR = 1.17, p = 0.40) and AD (HR = 1.38, p = 0.20, Figure 2 ).

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After covariation with total tau, we found seven nominally significant markers in plasma and one nominally significant marker in CSF.

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Both the unadjusted Kolmogorov-Smirnoff test (D = 0.18124; p < 2.2 × 10 −16 ) and analysis of covariance (ANCOVA) adjusted by age at DNA sampling and APOE genotype (F = 68.0, p = 2.54 × 10 −16 , Table S2 ) yielded highly significant results in the models including all available men in our cohort.

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