Preventing metastatic recurrence in low-risk ER/PR + breast cancer patients-a retrospective clinical study exploring the evolving challenge of persistence with adjuvant endocrine therapy.

Lymph node involvement has produced mixed results in the literature [ 55 , 56 ] and in our study this was the only clinicopathologic factor that trended toward having an effect with 26% of persistent patients having lymph node involvement compared with 18% of non-persistent patients, but this did not reach statistical significance ( p = 0.20).

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The IBIS 2 study showed a significant trend toward non-adherence in women on anastrozole who reported gynecologic symptoms.

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