Gp130 is expressed in pancreatic cancer and can be targeted by the small inhibitor molecule SC144.

J Cancer Res Clin Oncol · 2023 · PMC9889481 · PMID 36495330

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a clear trendno p-value reported

Although statistical significance was only found for 5 μM SC144 at 24 h (IL-6) or 6 h (OSM), also lower doses of 2 and 3 μM SC144 showed a clear trend of STAT3 phosphorylation inhibition respectively.

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showed a trendno p-value reported

Patients expressing epithelial gp130 showed a trend for poorer progress-free survival (median 15.0 months, IQR 7.1–29.7) than patients with no epithelial gp130 expression (median 19.1 months, IQR 10.5–31.8) but without significant prognostic relevance ( p = 0.247).

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