The patient’s Vδ2 + cells showed an overall trend towards higher perforin expression with a significantly increased response to anti-CD3/28 and combination of zoledronic acid and IL-2 (Fig. 3f ).
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Characterization of Expanded Gamma Delta T Cells from Atypical X-SCID Patient Reveals Preserved Function and IL2RG-Mediated Signaling.
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The Pro58Ser/Phe178Leu variant showed a trend towards higher total protein expression level compared to Pro58Ser variant, but this did not reach statistical significance (Fig. 7 d ).