FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans.

Consistent with our computational model prediction, we observed a significant reduction in the SAM/SAH ratio for FMO-2 OE (hypomethylation) and a significant trend in SAM/SAH ratio corresponding to fmo- 2 expression by ANOVA trend analysis.

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Furthermore, betaine, folic acid, serine, and cystathionine levels all show a trend with fmo-2 expression, but they did not reach statistical significance below a 0.05 p -value (Supplementary Fig. 1 ).

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In our study, we observe a level of methionine that shows an increasing trend with increasing fmo-2 expression level (Fig. 1d ).

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