The number of responding neurons decreased across the 3-day fear learning protocol, although this trend did not reach statistical significance ( Figure 1M–O ; Figure 1S , open symbols; p=0.117; Χ 2 df=2 = 4.292, Chi-square test).
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A striatal circuit balances learned fear in the presence and absence of sensory cues.
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This showed a trend towards an increased freezing during the no-CS epochs in the Arch group as compared to eGFP controls, although this difference did not reach statistical significance ( Figure 6G , right; p=0.0512, F 1,17 = 4.40; two-way repeated measures ANOVA, N=8 and 11 eGFP and Arch mice, respectively).