APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice.

Although statistical analysis indicated that these effects did not reach significance, we observed a strong trend toward reduced GSK3β activity in transgenic THY-Tau22 mice ( p = 0.06) and a strong trend toward a rescue by APPsα expression ( p = 0.05).

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(2015) who found in THY-Tau22 mice enhanced hippocampal levels of activated GSK3β, as indicated by an increase in phosphorylation at the Tyr 216 epitope and similar to our study a slight trend toward decreased phosphorylation at the inhibitory Ser 9 epitope.

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In stratum pyramidale, MC1 + Tau species were also reduced by APPsα, but values failed to reach significance ( Figure 8C ; THY-Tau22-Venus 100.00 ± 9.06% vs.

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THY-Tau22 mice injected with AAA-Venus showed a trend toward less inhibitory pGSK3β Ser9 (normalized to total GSK3β), indicating increased GSK3β activity compared to wild type littermate controls ( Figure 4D ; LM-Venus: 100.00 ± 11.25% vs.

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