Early-life exposure to per- and polyfluoroalkyl substances and infant gut microbial composition.

Environ Epidemiol · 2023 · PMC9916123 · PMID 36777525

Europe PMC DOI

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0.1700

closest p · 3.4× alpha

0.1700

boldest claim

The sentences

did not reach statistical significanceP = 0.17not close (p > 0.1)

Diversity measures Milk PFOS concentrations were associated with increased gut bacterial diversity at 6 weeks of age, although this estimate did not reach statistical significance [β = 0.11 change in Shannon Index per doubling PFOS exposure (–0.05, 0.27), P = 0.17 in fully adjusted multipollutant models].

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nominally significantno p-value reported

In feature analyses, we considered a Benjamini-Hochberg adjusted false discovery rate of q < 0.1 to be statistically significant and a P < 0.05 to be nominally significant. 42 All analyses were conducted in R v4.2.0 using the RStudio v2022.02.3 + 492 environment. 43 , 44 Results A total of 134 infants were included in either or both 6-week (n = 116) or 1-year analyses (n = 119).

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