However, few cases with high l-CaD expression received 5FU alone and showed a trend to have poor survival that did not reach statistical significance.
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Immunohistochemical Expression Analysis of Caldesmon Isoforms in Colorectal Carcinoma Reveals Interesting Correlations with Tumor Characteristics.
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The sentences
In contrast, l-CaD expression showed a trend for association with poor survival after 5FU therapy alone, suggesting that it predisposes to resistance to 5FU.