Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced Gastroenteropancreatic Neuroendocrine Carcinoma.

Assessing the subgroups, with five or more cases in each primary site (Table 1 ), some numerical differences were observed (Fig 3 B), but these did not reach statistical significance.

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Stratifying patients into subgroups according to degree of liver involvement, we found a significant trend of increasing proportion of tumor mutations detected in liquid biopsies, with increasing disease burden ( P trend = 1.2 × 10 –4 ; Fig 3 A).

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