Dieting reverses histone methylation and hypothalamic AgRP regulation in obese rats.

Front Endocrinol (Lausanne) · 2023 · PMC9930686 · PMID 36817590

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

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boldest claim

The sentences

showed a trendp<0.001actually significant

While HF-C showed a trend towards lower body weight, only HF-CR had a significant decrease in body weight (p<0.001) ( Figure 1B ).

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approaching significancep =0.05actually significant

After 24 hours, rats that were administered JIB-04 consumed fewer grams (approaching significance) of chow compared to controls after each injection (injection 1: t ( 25 ) = 2.04, p =0.05; injection 2: t ( 25 ) = 1.78, p =0.08; injection 3: t ( 25 ) = 1.86, p = 0.07) ( Figures 4C ). 24-hours after the 3rd drug administration, the rats were subjected to the OFT to check general toxicity of the injected drug by measuring anxiety-like behaviours and locomotion.

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