Association of Higher Ocrelizumab Exposure With Reduced Disability Progression in Multiple Sclerosis.

Disability Progression in Patients With PPMS Confirmed Disability Progression Measured With the EDSS In patients with PPMS, exposure dependency analysis of 24 W-CDP was directionally consistent with RMS but did not reach statistical significance (high vs low exposure: HR 0.76 [95% CI: 0.54–1.06; p = 0.099]); HRs of 24 W-CDP and associated Kaplan–Meier analyses (grouped by quartile and high vs low exposure, and BMI quartile and high vs low BMI) and overall 24 W-cCDP (grouped by quartile and high vs low exposure) are presented in Figures 1 and 2 , respectively.

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30 In the present analysis, a consistent pharmacodynamic effect was observed in patients with RMS, where an incomplete B-cell depletion or higher B-cell counts in blood before the next infusion showed a trend toward elevated risk of disease progression over the DBP and OLE, and higher median B-cell levels during the 96-week DBP showed a trend for more disability progression in the OLE.

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