Deep phenotypic analysis of psychiatric features in genetically defined cohorts: application to XYY syndrome.

Although most measures showed a trend towards less severe scores in prenatally vs. postnatally diagnosed individuals (especially for ASD-related features), scores in the prenatally diagnosed subgroup remained significantly elevated (median z > 2) for most measured domains, and the ranking of domains remained highly stable between the subgroups.

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Finally, rates of psychiatric diagnosis tended to be lower amongst the prenatally diagnosed subgroup of XYY individuals relative to the postnatally diagnosed subgroup, although these differences did not reach statistical significance (Table 2 ).

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