5 C, D, there was a significant trend between high miR-192-5p levels at T4 and both OS and LFS, and the correlation was stronger ( p = 0.03) in case of responders, as compared with patients losing response and non-responders.
In our cohort, only at T4 and T8 there was a statistically significant difference of miR-192-5p amount in responder patients compared with healthy subjects (T4: Student’s t test, p < 0.05, 95% CI − 7.72 to 0.69; T8: Student’s t test, p < 0.05, 95% CI − 6.93 to − 0.42), while the changes between the other subgroups and healthy subjects did not reach statistical significance.