After induction of subretinal fibrosis, BMDMs from aged mice showed a trend of increment in the production of CCL2, VEGF, OPN, and Angiopoietin-2 (Ang-2) compared with BMDMs from young mice (Additional file 1 : Fig.
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Old age promotes retinal fibrosis in choroidal neovascularization through circulating fibrocytes and profibrotic macrophages.
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The correlation between lesion size and bone-marrow CD45 + collagen-1 + cells did not reach statistical significance (Fig. 3 L).