Melatonin Activates Anti-Inflammatory Features in Microglia in a Multicellular Context: Evidence from Organotypic Brain Slices and HMC3 Cells.

Biomolecules · 2023 · PMC9952958 · PMID 36830742

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showed a trendno p-value reported

As shown in Figure 3 b, the total number of microglial cells showed a trend towards an increase, which reached significance in the presence of MEL alone or in combination with LPS added on day 1 (MEL + LPS 1°).

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did not reach statistical significanceno p-value reported

The same effects were confirmed by immunocytochemical analysis of nuclear SIRT1 (representative images shown in Figure 7 c), although in this case MEL action against LPS did not reach statistical significance ( Figure 7 b). 4.

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