Rare mutation-dominant compound EGFR-positive NSCLC is associated with enriched kinase domain-resided variants of uncertain significance and poor clinical outcomes.

We also divided all patients by the type of first-line EGFR TKIs they received, and the second-generation TKI treatment showed a trend toward having the worst PFS ( P = 0.23; Fig. 4 C).

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However, the results did not reach statistical significance due to the limited sample size of the subgroups (Additional file 1 : Fig.

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