Canagliflozin Improves Myocardial Perfusion, Fibrosis, and Function in a Swine Model of Chronic Myocardial Ischemia.

J Am Heart Assoc · 2023 · PMC9973570 · PMID 36583437

Europe PMC DOI

hedged sentences

0.0650

closest p · 1.3× alpha

0.0650

boldest claim

The sentences

a strong trendP =0.065so close (0.05 < p ≤ 0.1)

Immunoblot experiments of fibrotic markers in ischemic myocardium showed decreased Jak/STAT signaling as indicated by decreased expression of Jak2 ( P =0.021), and a strong trend toward decreased expression of phosphorylated STAT3 ( P =0.065), and the ratio of phosphorylated STAT3/STAT3 ( P =0.065).

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approached significanceno p-value reported

Additionally, given the large animal model, we have a relatively small sample size of 8 animals per group, and there were several trends that approached significance that may have been unmasked by a larger sample size.

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a nonsignificant trendno p-value reported

There was a nonsignificant trend toward increased cardiac output in the canagliflozin‐treated pigs compared with controls.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.