PI3K pathway mutation predicts an activated immune microenvironment and better immunotherapeutic efficacy in head and neck squamous cell carcinoma.

World J Surg Oncol · 2023 · PMC9979448 · PMID 36864522

Europe PMC DOI

hedged sentences

0.6800

closest p · 13.6× alpha

0.6800

boldest claim

The sentences

did not reach statistical significancep = 0.68not close (p > 0.1)

Results The Kaplan-Meier survival curves displayed that PI3K pathway mutation predicted observably prolonged overall survival (OS) in the immunotherapy cohort MSKCC-2019 ( p = 0.012) but did not reach statistical significance in the non-immunotherapy cohorts TCGA-HNSC ( p = 0.68) and MD-Anderson ( p = 0.68).

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failed to reach statistical significanceno p-value reported

In addition, CNA analysis at focal and chromosomal arm levels exhibited a higher frequency of copy number deletions in the wild group ( P < 0.05), while copy number amplifications failed to reach statistical significance, although there was a corresponding trend ( P > 0.05; Fig. 2 A and E–H).

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