Evidence for dopaminergic involvement in endogenous modulation of pain relief.

Similar to these results, we found here that endogenous pain modulation, assessed using self-reported pain intensity, induced by winning was associated with participants’ scores on novelty seeking in the NISS questionnaire (Need Inventory of Sensation Seeking; Roth and Hammelstein, 2012 ; subscale ‘need for stimulation’ (NS)), although this correlation failed to reach statistical significance after correction for multiple comparisons using Bonferroni-Holm method ( r =–0.412, p=0.073).

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The higher average pain modulation under naltrexone compared to placebo found in VAS ratings (naltrexone: -10.09, placebo: -7.31, see Table 1) suggests an increase in pain modulation by naltrexone compared to placebo, although this did not reach statistical significance, which is the opposite of what we had expected (see comment #11).

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