Apolipoprotein E loss of function: Influence on murine brain markers of physiology and pathology.

Aging Brain · 2022 · PMC9997145 · PMID 36908879

Europe PMC DOI

hedged sentences

0.0544

closest p · 1.1× alpha

0.0544

boldest claim

The sentences

approached significancep = 0.0544so close (0.05 < p ≤ 0.1)

In contrast, by 6 months of age, reduction of SYP levels approached significance ( Fig. 4 B; p = 0.0544); here, PSD95 levels were also lower in ApoE−/− compared to WT controls ( Fig. 4 B; p = 0.0114, −15 %).

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a strong trendno p-value reported

Furthermore, ApoE−/− animals also exhibited neuroinflammatory changes (neonatal mice displaying increased Iba1 levels and 6-month old animals demonstrating a strong trend), indicative of microgliosis.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.