Barely Significant

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highly significantp < 0.000010.0× alphaqualifiedgold
Similarly, the liraglutide versus placebo/standard treatment subgroup (Figure 4 ) showed a highly significant reduction in BMI (MD: −1.75 kg/m2; 95% CI: −2.38 to −1.12; p < 0.00001), again with no heterogeneity (I2 = 0%), reinforcing the reliability of liraglutide’s effect in weight reduction.
highly significantp = 0.00010.0× alphaqualifiedgold
The percentage reduction from baseline disability scores revealed substantially greater therapeutic efficacy in group B, with a mean reduction of 65.20% with a standard deviation of 14.67% compared to 46.26% with a standard deviation of 18.42% in group A, yielding highly significant differences (t = -4.187; p = 0.0001) and a large effect size (Cohen's d = 1.183).
highly significantp < 0.00010.0× alphaqualifiedgold
Clustered bivariate analysis ALP elevation is the dominant discriminator of metastatic-burden quartiles; higher categories (≥ 122 U/L and especially ≥ 222 U/L) are markedly over-represented in Q2 and Q3, with highly significant likelihood-ratio (LR) tests (p < 0.0001).