Barely Significant

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A decreasing trend in mortality was observed across all 21 regions, with East Asia showing the most substantial decrease (EAPC = −9.68, 95 % CI -9.98 to −9.38, Table 1 ).Among the SDI regions, the low SDI region exhibited both the highest number of deaths (389,824, 95 % CI 309,207 to 484,819) and the highest mortality rate (82.44, 95 % CI 65.39 to 102.53) in 2019.
These figures demonstrate a notable trend whereby the majority of bleeding incidents (depicted in purple) occurred in patients with elevated aPTT levels, while AT levels frequently dropped below 80 %. 3.3 Prediction model by logistic regression Based on the results of bivariate analysis, COVID-19 (OR: 3.504; 95 % confidence interval [CI]: 1.415–8.681, p = 0.007), acute liver failure (OR: 8.0000; 95 % CI: 1.692–37.822; p = 0.009), high AT level (%) (OR: 1.036; 95 % CI: 1.003–1.071, p = 0.035) were determined as independent predictors of hospital mortality in adult patients undergoing V-V ECMO due to severe ARDS.