Excerpts

All inter-device correlations elicited a highly significant correlation with r-values of 0.72–0.86 (all p < 0.0001, Table 2 , Supplemental Figure S4).

Although there was no significant difference between the strains in the accumulation of mitochondrial point mutations in untreated cultures, upon irradiation, even at the lowest UV dose of 5 J/m 2 pol30-K164R cultures exhibited a highly significant ( p < 0.0001) increase of mitochondrial point mutations in relation to their POL30 + counterparts at the same dose (Fig. 3 c).

Pairwise analysis of the LysoTracker levels for the 24 patient cell lines included in both studies showed a highly significant correlation with previous measurements (Spearman r = 0.76, p < 0.0001, Fig. 1 ), demonstrating the reproducibility of LysoTracker staining in cultured primary fibroblasts from individuals with NPC1.

Furthermore, in all four regions, pairwise comparisons (Dunn’s test) of the frequency distributions of TBA values among locations with defoliation, mortality, or no damage showed highly significant ( p < 0.0001) differences between the three groups (Fig. 5 , Table 2 ).

A linear trend test across adjusted ORs revealed a highly significant positive correlation ( P < 0.0001), indicating that higher urinary microalbumin levels were associated with a progressive increase in MetS risk.

The ANOVA results for the Naphtha cut of heavy oil which are presented in Table 10 , indicate that the model as a whole is highly significant, with a p value of < 0.0001 and an F-value of 1518.48, suggesting that the factors included in the model explain a substantial portion of the variability in naphtha yield.

The correlation between Gower’s distance matrices based on qualitative and quantitative traits was highly significant (r = 0.41; P < 0.0001).

The results indicated that drug release from all the screened formulations was very highly significant compared to that from drug suspension ( P < 0.0001), thus suggesting a higher bioavailability potential of the drug.

Correlations were highly significant [tMax: minimum r(30) = 0.78; yMax: minimum r (30) = 0.93; p < 0.0001].

The interaction between current density and treatment time plays a decisive role in coating development, with a highly significant effect on hardness (IT = − 18.25, p < 0.0001).

The spine density per 100 μm of dendrite was 30.7 ± 3.7, compared to corresponding values of 15.9 ± 5.1 for the GRPR cells 18 , and this difference was highly significant ( P < 0.0001; t-test; Fig. 8 e).

The log rank test analysis indicated that the difference between the survival curves is highly significant ( p < 0.0001).

Viral DNA load of NS1 correlated significantly with VP1/2-DNA load (p = 0.0148; Pearson r = 0.1228; r 2 = 0.01509) and furthermore correlation of NS1- to VP1/2-RNA loads was highly significant (p ≤ 0.0001; Pearson r = 0.8817; r 2 = 0.7775).

The LMM (R2= 0.4) reveals a highly significant influence of the fixed effect accommodation demand (F(4, 97.01) = 9,3966, p < 0.0001) while the fixed effect session (F(1, 97.67) = 0.1247, p = 0.7248) and the resulting interaction effect (F(4, 97.26) = 0.148, p = 0.9635) between accommodation demand and session showed no significant influence.

This was confirmed by the p values of the chi-square for the log-rank test that was not significant for the MAI (p = 0.3042), close to significance for MED (p = 0.0651), and highly significant for FA2 and PC2 (both, p < 0.0001).

A highly significant difference was found between the parental lines in MI ( P ≤ 0.0001), with 53.9 ± 1.97 and 70.7 ± 1.97 for IGC119 and Harari, respectively (Fig. 1 b).

2 ), indicated by a highly significant interaction between the N fertilisation treatment and the D BGL effect (Chi square = 132.2, P < 0.0001).

The impact of measurement time on USCL changes in the 2nd cohort comparisons was highly significant (p < 0.0001).

2B ) both showed highly significant differences in their growth curves after iron supplementation (p < 0.0001).

The fitted regression was highly significant (Model p < 0.0001; R2 = 0.9025; F = 40.1) and the lack-of-fit was non-significant ( p = 0.2151), confirming that the model explains solubility well within the studied domain.

However, when we transiently expressed a constitutively active form of Rab8a, using the same promoter (t aCP:mCherry-Rab8aCA ), we observed highly significant rescue of OS development in the mutant PRs expressing this transgene (Fig. 6D–D’ and red circles in E, p < 0.0001, Student’s t -test), with a majority of expressing PRs now displaying a nicely elongated OS.

However, the Spearman correlation coefficient was highly significant (ρ = − 0.772; p < 0.0001), indicating a statistically significant relationship between BBSP amount and LAMP T p .

Statistical comparison between days 40 and 120 was highly significant (p < 0.0001).

As expected, only very minor differences were noted between the antibodies with and without LS (Table 1 , Suppl Table S1 A,B), with highly significant correlation between values: for each pair of antibodies, both IC50 values and IC80 values correlated with Spearman’s rho of 0.94 or higher and p < 0.0001; and the median IC50s were no more than twofold different, which is within experimental error for this assay 17 .

Using a mixed model to allow for correlation of the data, we found a highly significant difference (p < 0.0001) between weak and strong tapping ( Figure 1d ).