Barely Significant

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highly significantp < 0.0010.0× alphaqualifiedgold
At protein level, serum S100A12 protein concentration was highest in the SIMD group (19.60 ± 3.36 ng/ml), followed by the non-SIMD group (14.79 ± 2.92 ng/ml), and lowest in the control group (10.33 ± 1.97 ng/ml), with highly significant differences between groups (all p < 0.001) ( Figure 2B ).
a trend towards significancep = 0.0010.0× alpha
The relationship between WM and IGF2BP1 methylation was mainly due to shared genetic and environmental factors, although unique environmental influences also showed a trend towards significance ( β B = −9.8×10 −3 , p = 0.001; β W = −2.9×10 −3 , p = 0.086) (see Table 4 and Figure 3 ): 10-point rises in the pair's mean WM score (i.e., WM's familial component) would account for an approximate reduction of 9.8% in methylation, whereas a 10-point advantage over a duo's average WM value would correlate with a 2.9% methylation level reduction.