Applying the previously established MRD threshold of VAF >0.01% by NGS/DNA in the enlarged cohort, resulted in 37 patients (12%) with relatively high-level mutant NPM1 disease and a highly significant increased risk of relapse (4-year CIR: 52.8% MRD + vs 28.1% MRD – ; HR, 2.56; 95% CI, 1.54-4.25; P < .001; Figure 3 D), and inferior OS ( P > .001; supplemental Figure 5 D).
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The table shows highly significant ( P < 0.001) differences were detected among generations for both crosses 1 and 2.
Bartlett’s test of sphericity has to be highly significant ( p < 0.001) [ 39 ].
However, it showed a decreasing trend by grade among boys (9th grade: 8.09 ± 1.5; 10th grade :7.98 ± 1.52; 11th grade: 7.88 ± 1.57; 12th grade 12: 7.64 ± 1.73; p < 0.001) and girls alike (9th grade: 8.12 ± 1.45; 10th grade: 7.91 ± 1.50; 11th grade: 7.86 ± 1.53; grade 12: 7.85 ± 1.55; p = 0.018).
Although these percentages are rather low, they were highly significant as demonstrated by Fisher’s exact test ( p < 0.001).
In the intervention group, all subdimensions showed highly significant changes ( p < 0.001), with large effect sizes (Cohen’s d = 3.61, 3.64, 3.58, 3.70, and 3.75, respectively).
Statistical significance was defined as follows: P < 0.05 (statistically significant), P < 0.01 (highly significant), and P < 0.001 (extremely significant).
Irrespective of the sepsis definition, PSP was the only marker to demonstrate a highly significant interaction between time and group (sepsis versus no sepsis) ( p < 0.001) with a 3.3–5.5-fold increase within 72 h before the event of sepsis, whereas CRP, PCT, and WBC showed only mild undulations.
This difference in MCVs was extremely significant statistically ( P < 0.001).
There was a highly significant and very large effect of session ( F (2,30) = 35.42, p < 0.001, η 2 = 0.355), a significant medium effect of task ( F (5,75) = 14.7, p < 0.001, η 2 = 0.073) and a nonsignificant interaction ( F (10,150) = 0.96, p = 0.440, η 2 = 0.008).
Tables 1 and 2 shows that the mean MIC of AgNP particles lies between 2.82 ± 0.68 and 90 ± 22.36 μl/ml (p < 0.001 – highly significant) as compared to mean MIC of Chlorhexidine gluconate was seen between 150 ± 55.90 and 450 ± 111.8 μg/ml (p < 0.001 – highly significant).
Relative power analysis revealed a Cohen’s d of −0.53 for component C7 in the Alpha2 band, indicating a moderate-to-large effect size and a highly significant difference (p < 0.001) between the ACr and HC groups.
The interaction effect of surgical procedure and MLH was not statistically significant ( P = .093); however, a notable trend was detected through subgroup analysis: MLH was significantly positively correlated with graft resorption in the UEG ( P < .001), whereas such a correlation was not detected in the EG ( P = .120).
Interspecific differences in T 0 and T p were highly significant ( p < 0.001; Table 2A,B ).
The analysis of variance revealed highly significant genotypic effects ( p ≤ 0.001) for traits with moderate-to-high heritability (Table 1 ).
The survival probabilities for the highest and lowest METS-VF groups, as depicted by the Kaplan-Meier curve, exhibited a decreasing trend with prolonged follow-up (log-rank test, p < 0.001).
Highly significant differences were observed between the t 0 and 240 min samples (p < 0.001).
We also found that the effects of consumers’ perceived pleasure on consumers’ purchase intentions were highly significant (β=0.795, p<0.001), thus supporting H8.
The results were highly significant ( r =0.6563, P <0.001), indicating that the variations in codon usage are strongly correlated with the nucleotide content (i.e., GC content) of the genes.
The differences between treatment and placebo were highly significant ( P <0.001).
Replicating the effects observed at the end of rCPT stage 4 training, DBA showed a highly significant reduction in d ′ across the session that was not observed in C57 mice (strain × time bin interaction: F (2, 44) = 18.28, p < 0.001).
Even though both formulations had the same type of time distribution (exponential), the distribution rate parameters differed in an extremely significant manner on the Kolmogorov–Smirnov test ( p < 0.001).
The highest level was observed in the 40% combination group (CDDP 11.2 μM + ε-VNF 8.4 μM), reaching 4.3 ± 0.6 μM, which was found to be highly significant (*** p < 0.001).
3.4 Population genomic analyses For each RAD dataset, all pairwise comparisons of genetic differentiation ( F ST ) between clusters identified in STRUCTURE and AWCLUST were highly significant ( p ‐value <0.001).
RM-ANOVA showed a decreasing trend of the groin, leg, and back pain in the EG in the second to sixth hours after the trial (P < 0.001 for each area of pain measured), while in the CG groin, leg and back pain had an increasing trend (P < 0.001 for each area of pain measured) (Fig. 2 , 3 , 4 ).