Genes of known function were abnormally abundant (13/20; the difference from the proportion in the genome is highly significant, p < 0.001) indicating a non-random gene distribution.
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Comparison of the transcript abundance between promoter-methylated and promoter-unmethylated genes revealed a highly significant negative correlation ( p < 0.001) between gene expression levels and promoter methylation levels, especially in the CG and CHG contexts ( Fig 4B ).
These associations remained highly significant ( P < 0.001 for all) through sequential multivariate adjustment: first for other blood parameters (Model 1), then additionally for demographics (Model 2), comorbidities (Model 3), and finally angiographic severity (Model 4).
The effect of the year was highly significant ( p < 0.001), with total dry matter yield in 2024 being approximately 76% lower than in 2023.
Although CEA did not achieve statistical significance in the final multivariate model (P = 0.075), it was retained due to its established clinical relevance and borderline significant association in univariate analysis (HR = 1.009, 95% CI: 1.006–1.012, P < 0.001).
C3a-desArg levels in the 4 mM citrate group tended to be lower as compared to the 3 mM citrate group, but the difference did not reach statistical significance (main effect of time p < 0.001, citrate group p = 0.107 and interaction effect p = 0.246).
The significance levels for all data analyses in this study are defined as follows: p < 0.05 indicates significance, p < 0.01 indicates highly significant, and p < 0.001 indicates extremely significant.
One-way ANOVA revealed a highly significant effect of vibration class, with F(4, 3974) = 22,486.6, p < 0.001.
Region of interest analysis Both, left and right precentral cortex showed a highly significant reduction of the cortical thickness in ALS (left: t(26) = 3.76, p < 0.001; right: t(26) = 3.81, p < 0.001).
The lower prevalence of parasitism in the naïve catfish treatment was highly significant (Generalised Linear Mixed Model (GLMM) with binomial error distribution, n = 509 host clutches; naïve vs. experienced catfish: z = 4.31, P < 0.001; naïve vs. highly experienced catfish: z = 3.60, P < 0.001), but the probability of parasitising cichlid clutches did not differ between experienced and highly experienced catfish ( z = 0.75, P = 0.452) (Supplementary Table 2 ).
ANOVA showed a highly significant year effect on yield ( p < 0.001), whereas MG and Year × MG were not significant.
Additionally, treatment with LDL-MAA demonstrated a highly significant increase in the expression of this cytokine ( p ≤ 0.001) ( Figure 4 C).
The difference was highly significant (t = 3.8, p < 0,001).
There was a highly significant correlation between the expression levels of miR-222-3p and miR-26b-5p ( p = 0.001) (corrected p = 0.026), the expression of miR-222-3p and EBV-miR-BHRF1-2-5p ( p = 0.001) (corrected p = 0.026), and the expression of miR-26b-5p and EBV-miR-BHRF1-2-5p ( p = 0.001) (corrected p = 0.026).
Our two pairs were marginally significantly different from each other (wald = 9.73, P = 0.08) while lakes and streams were clearly significantly different in MHC allele composition (wald = 15.5, P<0.001).
Dynamic Balance Training Dynamic balance training over 4weeks induced a highly significant TIME effect ( Figure 3 ), more precisely an increase in training scores ( F 5.161, ∞ =92.141, p <0.001), but no significant GROUP effect was observed ( F 1.000, ∞ =1.188, p =0.278).
The RRSO and the three MSs were highly significant ( p < 0.001) based on the likelihood ratio test when comparing a model with RRSO versus no RRSO (the 3 MSs included) and a model with the three MSs versus no MS (RRSO included), respectively.
Correlation of the Stenosis Individual Characteristics with Flow Velocities LL showed a positive, moderate but statistically highly significant, correlation with PSV (r = 0.19) and EDV (r = 0.20); p = 0.001 and p < 0.001, respectively.
Season significantly influenced all traits except NS ( p < 0.001), while parity exhib-ited a very highly significant influence on all reproductive traits ( p < 0.001).
MPH and HPH treatments caused a highly significant reduction in FBS compared to the DOX group ( p < 0.001), indicating dose-dependent glycemic protection ( Fig. 6 ) (see Fig. 6 ). 3.4.
Using the ANOVA test, the difference was statistically highly significant with p < 0.001 (Table 2 ).
A highly significant correlation was, however, found between ROMs and CP oxidase activity levels in both goat kid and lamb sera ( p < 0.001).
Statistical evaluation showed strong positive Spearman rho correlation (r s =0.790) between Johnsen scoring and CDC25A-positive cells which was highly significant at p<0.001.
We conducted further analysis only with aIAB that was highly significant ( p < 0.001) in the univariate regression analysis after Bonferroni correction.
Tick mean abundance was significantly different among habitats, the effect of the transect as a random factor being highly significant ( p < 0.001) in all three models (i.e., for the two dominant species and the host community).