Barely Significant

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highly significantP < 0.00010.0× alphaqualifiedgold
Although interfamily variation was highly significant at both temperatures (all P < 0.0001, Table 2 ), the amount of variation at 7°C appeared to be greater overall than at 14°C (average range in time to hatching = 2.4 days at 14°C vs. 6.3 days at 7°C; stage at hatching = 0.87 vs. 1.6; size at hatching = 0.77 vs. 1.04).
highly significantp < 0.00010.0× alphaqualifiedgold
Statistical findings reinforced this approach: A one-way ANOVA on mean percent change in Cp showed a strong group effect [F(2,36) = 50.42, p < 0.0001)], with post hoc Tukey HSD tests revealing no significant difference between Non-Responders and Placebo (mean difference = 0.25%, p = 0.998), but large, highly significant differences between Responders and Placebo (mean difference = 35.74%, p < 0.0001) and Responders and Non-Responders (mean difference = 35.49%, p < 0.0001).
highly significantp < 0.00010.0× alphaqualifiedgold
Similarly, the percentage of positive fields for IL-13Rα2 expression in 2+ and 3+ positive specimens in IHC analysis demonstrated a highly significant trend in these specimens (well differentiated = 35.0%, moderately differentiated = 82.0% and poorly differentiated = 94%; exact p < 0.0001) compared to PDAC samples with negative values of IL-13Rα2 (≤ 1+) ( Figure 1 D).
highly significantP < .00010.0× alphaqualifiedgold
Robustness Analysis FDR-adjusted analyses confirmed the stability of the main findings: several group-level effects remained highly significant after correction—most prominently the AI of lobules V, VI, VIIIB, and IX (e.g., Lobule IX Volume Asymmetry: F(1,95)=17.53, P < .0001, q = 0.0012, partial η 2 = 0.156) and the left-sided thickness and volume of Lobule IX (F(1,95) = 10.28, P = .0018, q = 0.0198, partial η 2 = 0.098).
highly significantp<0.00010.0× alphaqualifiedgold
For example, the mean serum creatinine level fluctuates around 95 μmol/l throughout the whole study period, but there is a slight positive (ie, upward) linear trend for males above 75 years, while for women there is a slight negative linear trend for all age categories while the overall linear (very slightly positive) trend is nevertheless highly significant (p<0.0001).