Excerpts

The difference among three genotypes was highly significant both in males (p < 1E-40) and females (p = 1E-33).

Notably, dipeptides, such as Val-Glu and Met-Gln, showed highly significant values in AP ( p -value > 10 −40 ) ( Figure 3 ).

In Family A, SNPs on chr-4 at physical locations 62,076,809 bp and 62,076,876 bp exhibited the strongest association; additional highly significant SNPs (−log 10 p >40) clustered between 60,613,763 bp and the end of chr-4.

The 6 most highly significant smoking CpGs were also the most highly associated with bladder cancer (smoking p -value < 10 - 40 , bladder cancer p -value < 10 - 10 ).

All correlations are highly significant (p < 1.0E-40).

Other miRNAs were not ranked at the top 30 of comparative activity mode (Methods), however they show highly significant differential activity (corrected WRS p -value < 1 e −40) and substantial activity in at least one of the populations (activity p -values below 1 e − 4 among at least third of cells in at least one population).

The PSs for TG (30 SNPs), LDL-C (28 SNPs), and HDL-C (60 SNPs) explained a relatively small, but highly significant, proportion of the variance (5.6 % [F = 157, P = 1.7 × 10 −40 ], 3.1 % [F = 99, P = 6.2 × 10 −27 ] and 5.1 % [F = 164, P = 1.1 × 10 −36 ]; Additional file 6 ) and were not associated with confounders (Additional file 7 ) with the exception of the HDL-C PS, which was associated with confounder neutrophil counts ( P value = 1.8 × 10 −2 ).

Category II SNPs (SNPs with less functional evidence than Category I) also showed highly significant enrichment for low P-values (fold enrichment 1.42; P = 2.60e-40) ( Table 3 ).

We found a large (n = 98) and highly significant (p = 2.8e−40) overlap between the splicing events regulated by QKI and RBFOX2 ( Figure 4 D).

Intima-Media Thickness and Genetic OAG Risk First, we validated the association between the OAG-GRS and OAG, which was highly significant ( P = 4.8 * 10 −40 ), with an OR of 2.44 (95% CI = 2.13–2.78) for each standard deviation increase in OAG-GRS.

The difference in fit of the 13 models was highly significant ( p = 8 × 10 −40 , ANOVA), but there was no significant difference in the fits of the five top models, all of which incorporated a perseverative learning mechanism: Perseveration/Reward-learning model (PR model, ref. 36 ); differential forgetting Q -learning 33 ; ideal observer with perseveration (see Methods); ideal-observer Bayesian filters with perseveration for either a generic probabilistic reversal-learning task (see Methods), or a generic drifting reward probability task 37 .

Moreover, the SII demonstrated a consistent annual increase, with regression results indicating extremely significant statistical relevance (P = 9.3E−40).

In continuous light, there was a highly significant correlation between sister cell generation times ( R = 0.87, P < 1 × 10 –39 , Fig. 4c ), suggesting that the observed variation in generation times across all cells was not entirely stochastic.

A highly significant reduction ( p = 2.3 × 10 –39 ) in the number of Candida colonies was observed in the treatment arm when comparing pre- and post-study results.

falciparum ’s large proteins displayed unique and parasite-specific annotations, with a highly significant presence of host cell binding functions ( P = 3.21e−39) compared to the rest of the proteome.

S4b ), we found a highly significant peak on chromosome 17 (Fig. 6a , Supplementary Data 5 and 6 ) where the lead variant was an intergenic SNP upstream of the BMP2 gene (chr17:15643342:C>T, P = 3.45 × 10 − 39 ).

Remarkably, 35 insertions are located at common insertion sites (CISs), a highly significant result (Fisher's exact test p = 7.4×10 −39 ) ( Table 1 ).

These results were corroborated by the analysis of functional pathways using the ConsensusPathDB 25 (Methods); gene sets showed highly significant overlaps ( P <7.66 × 10 −39 –2.38 × 10 −05 ) with pathways involving OR and GPCR-related signalling and signal transduction, (extra-cellular matrix related) processes of inter-cellular communication, immunoregulatory processes and membrane-linked drug transport.

4c ) show that the TE and ICM nuclei in blastocyst embryos have highly significant differences in the mean nuclear dry mass density ( p -value = 8.11e−39), while the differences for cleavage state embryos are nonsignificant ( p -value = 0.0105).

To further investigate the significance of these directional findings we estimated the differences in the slopes using z-scores and demonstrated that for 31 of the 35 genes the differences were highly significant (Bonferroni corrected p<1×10 −38 ) ( Supplementary Table 4 ), thus strongly suggesting these were not chance observations.

Using a logistic regression model, we found that several factors had a highly significant influence on whether a proximal eQTL was detected as an aiQTL; namely, the distance of the eQTL from the TSS (P = 1 × 10 − 38 ), the number of samples with more than one allele-specifically mapped read (P = 1 × 10 − 88 ), the log P value of the eQTL (P = 3 × 10 − 174 ), the minor allele frequency of the eQTL (P = 2 × 10 − 44 ) and the median number of allele-specifically mapped reads (among samples with more than one allele-specifically mapped read; P = 0.008).

Interestingly, in a joint model where both rs970740 and rs6025 were used as covariates for predicting cg16548605 variability, the effect of rs970740 was highly significant (p = 1.05×10 −38 ) but that of rs6025 was not (p = 0.90).

Similarly, Table 4 reveals a highly significant effect of elevation height on PV efficiency (F = 134.21, p = 1.31 × 10– 38 .

GO enrichments for the lightgreen module are highly significant for “secretory granule” (p=2.14E-38), “secretory vesicle” (p=1.96E-36), and different specific neutrophils-associated terms such as “neutrophil activation involved in immune response” (p=1.04E-35), “neutrophil degranulation” (p=1.04E-35), “neutrophil activation” (p=2.00E-35), and “neutrophil mediated immunity” (p=2.64E-35).

We measured the relative abundance of the total ether-linked lipids and observed a highly significant elevation ( p -value = 2.94E-38) of total ether-linked lipids at 48 h post virus infection ( Figure 5C ).