Excerpts

26 , 28 - 31 A subsequent meta-analysis, which included 5,159 patients with AIS and 17,840 controls, reported a highly significant association with this SNP, with a P = 1.22 × 10 -43 for both men and women, and an even stronger P = 2.94 × 10 -48 for women only. 32 The present study established a significant association between the LBX1 polymorphism rs11190870 and AIS susceptibility ( P < .001), consistent with prior research conducted across diverse populations, particularly in East Asian cohorts.

The possible correlation between the allele frequency of SNP1 and wool production was extremely significant ( P = 2.50E-43) ( Fig. 3 d ).

To compare our findings to a genetic variant with known association with neurodegenerative diseases and aging, we made similar analysis with the frequencies of APOE ε4 allele, which showed a highly significant decrease with age ( p = 3 × 10 −43 ).

This finding was highly significant (p = 4.5×10 −43 ).

Using various carbohydrate-deficient transferrin indices, and adjusting for alcohol intake, a recent GWAS isolated the highly significant independent effects of variants in the transferrin ( TF , P =5.5 × 10 −43 ), and phosphoglucomutase 1 ( PGM1 , P =2 × 10 −9 ) genes on carbohydrate-deficient transferrin. 126 Neuroimaging phenotypes Neuroimaging outcomes are promising new endophenotypes for addiction.

The concordance between SomaModules and the optimal WGCNA clustering is highly significant (Fisher’s exact test p -value = 10 –42 ).

The difference between the observed T:B conjugate rate, and that predicted to arise by chance, was highly significant at up to P = 10 -42 .

The top TB network was highly significant (p = 10 −42 ) and included 20 focus genes implicated in susceptibility to Mycobacteria tuberculosis infection in a 35 gene network ( Table 1 , Fig 4 ).

Although this overlap is highly significant ( P < 1.66e −42 ) it shows that even within the same species larger differences in genes detected to be bound by FoxP3 can be expected either due to the experimental design like cell lines or stimulation or due to genetic and biologic variance.

Segregation analysis gave a highly significant association between the C allele and disease (p = 1.8×10 −42 ).

We found a highly significant correlation between both measurements in plasma samples, as shown in Fig. 1 a ( p = 2.6 × 10 −42 , r 2 = 0.902).

This difference was highly significant (Kruskal–Wallis χ2=185.15, P =3.64×10−42; Wilcoxon BH-adjusted P =3.66×10−42) ( Fig. 4b ).

4C , NMI and DRAM1 show a highly significant correlative expression with correlation coefficient (CC) of 0.71 and p < 3.7e-042.

Furthermore, there was a weak but highly significant negative correlation between the number of paralogs for a gene and its d N /d S ratio compared with orthologs (Spearman’s rank: r s = −0.131, P = 4.33 × 10 −42 ), suggesting that genes that are retained as paralogs tend to be under stronger purifying selection.

There is also a mild but highly significant correlation between the total number of targets involved in a combination and percentile of cell lines in which it is synergistic (Spearman’s ρ = 0.21, P = 6.25 × 10 −42 ), (Fig. 6A ).

The neighboring gene Pearson correlations were also found to be highly significant ( C. dubliniensis/C. albicans Pearson correlation = 0.218, p = 6.4 × 10 -42 ; C. tropicalis/C. dubliniensis Pearson correlation = 0.103, p = 9.8 × 10 -10 ).

Here, using genome sequences from 11,670 women, we observed a highly significant association between a stress-related disease, major depression, and the amount of mtDNA (p = 9.00 × 10 −42 , odds ratio 1.33 [95% confidence interval [CI] = 1.29–1.37]) and telomere length (p = 2.84 × 10 −14 , odds ratio 0.85 [95% CI = 0.81–0.89]).

IPA identified a highly significant network ( p < 10 −41 ) containing 20 of the 64 (31%) input genes and 15 bridging genes ( Figure 2 ).

This result is highly significant (p=10 –41 , exact ranks test, MATLAB signrank ) and holds for all tested pitch classes in the pair ([0,3,6,9], Figure 4D ).

A t-test comparison at TSS for the random sample and the origin peaks demonstrated a highly significant difference (p<10 −41 , Fig.

Chi-square tests yielded the most highly significant results for terpenoids ( p = 1.2 × 10 −41 ), amino acids and derivatives ( p = 1.6 × 10 −35 ), flavonoids ( p = 3.1 × 10 −33 ), lipids ( p = 4.8 × 10 −15 ), flavonols ( p = 1.8 × 10 −12 ), phenolic acids ( p = 2.6 × 10 −12 ), and flavones ( p = 1.1 × 10 −11 ). 3.2.

Although Aβ and tau oligomer levels showed a highly significant correlation (Spearman r = .541, p = 2.7 × 10 −41 ), no increase of tau oligomer levels regarding the disease stage was observed (Figure 1B ).

cerevisiae proteasome genes, the enrichment of genes containing the known Rpn4p binding site was highly significant (GGTGGCAA; p < 6 × 10 –41 ).

A highly significant association was found between the two tests ( p = 6.09 × 10 −41 ).

When normalized, manual analysis accuracy for N-T tissues increased from 0.75 to 0.91, which was highly significant (p=7,72x10 -41 ).