The improvement of OSS was highly significant with a two tailed P < 0.0001 and 95% CI of this difference was 11.47-22.20.
Excerpts
Values of area under the ROC calculated from all 381 samples for all mutations displayed highly significant values when compared with all mutations (p=0.0001; binomial exact test) suggesting that any mutation signature is able, to partially discriminate other types of mutations (supplementary table S4).
Highly significant differences in both heading time and number of spikelets per spike were found between Eps-A m 1 alleles ( P <0.0001; Table 3 ; Fig. 1 ).
Effects of miR-485 on NOI were highly significant by one-way ANOVA ( F 4,25 = 26.15, p < 0.0001).
For example, for the red and yellow ecotypes, the correlations between F ST and gene density ( r = 0.415), recombination rate ( r = −0.208), and mean π ( r = −0.452) are substantial and highly significant ( p < 0.0001) at a very early stage of divergence.
The association of each of the cytological grading systems and the histological grading by SBR method was found to be highly significant with a P < 0.0001 as measured by Chi-square test.
This was confirmed by a hierarchic (nested) analysis of variance (ANOVA), which showed highly significant among-cell (subgroup) variability regardless of the parameter tested (P < 0.0001, peak amplitude, risetime, halfwidth, and foot duration were tested after logarithmic transformation, cubic-root of the charge was tested without transformation).
Intriguingly, the sorted IFNβ + Tip-DCs also stimulated the naïve T cells to proliferate in a highly significant manner (p < 0.0001 as compared to macrophages) and more efficiently than the sorted IFNβ/YFP − bona fide Tip-DCs ( Figure 6 ).
A t -test was performed to determine the statistical significance of the difference in measured angles between astrocytic processes for GDA and control groups, with a highly significant p value of < 0.0001.
p-Values were taken to be significant: *significant 0.05≥p>0.01; **very significant 0.01≥p>0.001; ***highly significant 0.001≥p>0.0001; ****highly significant p≤0.0001.
Except for lung cancer, there are strong and highly significant trends of increasing cancer risk with increasing height ( P < 0.0001 for colorectal cancer, malignant melanoma, breast cancer, ovarian cancer, and other cancers and P = 0.002 for non-Hodgkin lymphoma).
A highly significant heterogeneity was found among the studies ( I 2 = 82%, p < 0.0001) ( Figure 5 ).
This analysis revealed a highly significant effect of condition, F (2, 78) = 19.2, P < 0.0001.
Mann–Whitney U test revealed that 11 of 13 phyla (except Actinobacteriota and Nitrospirota) showed highly significant differences between rhizosphere and bulk soils ( Table S2 : **** p < 0.0001).
Results A highly significant relationship was found between SVA and C7_PSI, mediolateral amplitude of CoP displacements and age (adjusted R2=0.69, p < 0.0001).
Statistical analysis revealed a highly significant difference in LC 50 values among the treatments (F(3, 8) = 705.8, p < 0.0001).
A strong and highly significant correlation was observed between plasma and PBMC-expressed SDC3 levels ( r = 0.921; p < 0.0001).
In that study, Se-HBV’s relation to toxic effects of CH 3 Hg exposures was highly significant ( F = 161.0, p < 0.0001) and consistent (adjusted R 2 = 0.735).
The correlation between nucleotide diversity values for HVS1 and HVS2 obtained for all patients was highly significant but moderate (r = 0.441, P = .0001), indicating that both mtDNA regions experienced genetic diversification during HCV infection but at different rates.
The treatment effect was examined within each parity because the overall treatment by parity interaction was highly significant ( p < 0.0001).
28 , 29 , 31 ICIs-related VTE occurrence was not independently associated with shorter PFS (HR 1.82, 95% CI 0.93-3.55, P = .08) ( Figure 3A ), and highly significant heterogeneity was shown between studies (Cochran's Q statistic, P < .0001, I 2 = 89%).
Furthermore, a marked elevation of IL-10 was observed in the LR group, reaching a highly significant level ( p < 0.0001). 3.3.
For both survival traits, there was a highly significant line and sex term in the ANOVA ( P <0.0001), as well as a significant line by sex interaction ( P <0.0001).
The mean level of TIMP-1 in EDTA plasma from 143 patients with Dukes' stage D colorectal cancer was 240 ± 145 μg l −1 and a Mann–Whitney test demonstrated a highly significant difference between TIMP-1 levels in healthy blood donors and colorectal cancer patients ( P < 0.0001).
The Pearson’s correlation coefficient between these two maps was modest but highly significant (r=0.24, p<0.0001 for both smoothed and unsmoothed permuted data; confirmed through a permutation test shuffling voxel location across 100,000 iterations; Figure 2C ).