Excerpts

Differences between concentrations were highly significant (P < 0.0001; F 6,45 = 26.92).

At P90, 10 out of 10 eyes injected with the 150 K dose showed highly significant ONL preservation in the temporal region ( ~ 6 nuclei) compared to the untreated nasal region ( ~ 2 nuclei) ( p -value < 0.0001).

Using the same statistical procedure described for Figure 2 , this overlap between the experimental data and the theoretical prediction is highly significant ( P < 0.0001).

It is of note, however, that our results still demonstrate high mortality when the TLR3 −/− strain was infected by a high viral amount of IAV, although the difference between this group and wild-type animals is highly significant ( p < 0.0001).

In DRG cultures of both sexes, 17β-estradiol produced a highly significant (p > 0.0001) 3-fold induction of Il6 ( Fig. 5 A) and Cacna2d1 ( Fig. 5 B) expression.

The median levels are about 12.40 ng/mL in Q1, 12.06 ng/mL in Q2, 11.54 ng/mL in Q3, and 10.45 ng/mL in Q4, with highly significant differences between the quartiles ( P < 0.0001).

Moreover, the pseudogenes expression showed a highly significant positive correlation between pairs of genes: HERC2P2 and SDHAP1 (R = 0.626, p < 0.0001), HERC2P2 and AURKAPS1 (R = 0.233, p < 0.0001) as well as AURKAPS1 and SDHAP1 (R = 0.328, p < 0.0001).

This difference was highly significant (p < 0.0001).

Group differences in slopes of the habituation curves were highly significant ( F (2,86) = 26, P < 0.0001; EE versus SH and EE versus WR P < 0.001 Tukey HSD), with the EE group's curve being much steeper than those of SH or WR rats ( Fig. 2 D).

The model difference was highly significant ( p < 0.0001), the misfit term was not significant ( p > 0.05), and the fit R 2 was close to 1, which proved that the model was well fitted and the regression equation could be used to analyze the effect of the factors on the peroxide value.

A linear regression model fitted with HbA1c reduction as the outcome and baseline HbA1C as the predictor demonstrated a highly significant relationship R 2 =0.74; p<0.0001 ( figure 4 and online supplemental file 6 ).

On average, only 4.9 ± 0.7% of proliferating normal epithelial cells in TDLUs simultaneously expressed ER-α, compared with 27.6 ± 2.2% in HELUs, which was also a highly significant difference ( P < 0.0001).

Improvements were highly significant compared to baseline for nasolabial folds (mean D0: 2.7 (0.4) vs. mean D540: 1.7 (0.6), p < 0.0001) and marionette lines (mean D0: 2.6 (0.4) vs. mean D540: 1.7 (0.7), p < 0.0001) at 540 days post‐injection and at 450 days post‐injection for lips (mean D0: 1.0 (0.5) vs. mean D450: 1.2 (0.5), p = 0.0326).

The differences in gene-expression ratios corresponding to 1-, 1.5- and 3-fold dose changes on chromosome 2L are highly significant ( p << 10 -4 by ANOVA followed by Tukey HSD, Hodges-Lehmann, and Kolmogorov-Smirnov tests; see Materials and methods).

A two‐way ANOVA showed highly significant effects of treatment [F(1,59) = 126.4, p < 0.0001], gene [F(5,59) = 75.40, p < 0.0001], and their interaction [F(5,59) = 74.37, p < 0.0001].

benign or normal groups were highly significant ( p < 0.0001).

We found a highly significant correlation between the extent of intermingling and translocation frequency ( p < 0.0001; Figure 2 B), such that higher levels of CT intermingling increase the chances of double-strand breaks (DSBs) being involved in rearrangements with other chromosomes.

This effect became highly significant ( p < 0.0001) after exclusion of noninformative studies increasing the RR; however, this analysis was based on two studies, one of them including the so far largest published cohort of screened individuals with GA1 1 (Fig. 4 ).

Shown in Supplementary Figure 4 , gene set enrichment analysis (GSEA) of differentially expressed genes (fold change > 3 and q-value <0.05) between WFA treatment and DMSO groups revealed a highly significant enrichment in expression of apoptosis-related genes by WFA at both 6 h (false discovery rate (FDR) q-value = 0.0001; family-wise error rate (FWER) p-value = 0.0001) and 12 h (FDR q-value = 0.0001; FWER = 0.008).

The Cd (ng/mL) levels in the blood of exposed workers were significantly higher than those in unexposed individuals, with mean values of 85.8 ± 0.83 versus 43.7 ± 3.07, respectively; differences were highly significant (p ≤ 0.0001).

Scutum and sensilla size variation There was no significant difference in the (seven-landmark) CS of S1 (0.059 mm) and S2 (0.060 mm) (P = 0.2058), and also no significant difference in the scutum perimeter of S1 (0.182 mm) and S2 (0.184 mm) (P = 0.2058), but there was a highly significant difference in size (P < 0.0001) between the perimeters of sensilla S1 (0.047 mm) and S2 (0.050 mm) ( Fig. 3 ; Table 3 ). 3.1.2.

Highly significant ( P < 0.0001) genotypic effects on TGW and GL were detected in L2, L3 and L4, and the enhancing alleles were all derived from MY46.

In contrast, both TCEP- and saline-treated animals showed a highly significant increase in nasal airspace ( Figures 4B, C ; p < 0.0001; n = 29).

The increase was highly significant ( p = 0.0001) with both htyr doses at 24 h, coinciding with a complete closure of the cell-free space ( Figure 2 B).

The main effect of strain was highly significant ( F 35,119 = 5.909, p < .0001).