Barely Significant
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“a decreasing trend”

47,181 sentences · 47,181 papers · 78,848 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

Nonetheless, we did find a decreasing trend in the use of PDS for both stages IIIC and IV patients and an increased rate of NACT, far greater with stage IV disease than stage IIIC, a pattern also noted by Meyer et al. 20 Similar to the study of Thrall et al, 19 we found that in stage IV disease alternatives to primary surgery were increasingly used: CT alone was provided more frequently than NACT, and a significant proportion of patients receive surgery alone or no treatment.
Analysis of the general health condition showed that the mean ages of elderly people in the 3 different years were relatively close, and the differences in the sex ratio were not obvious; however, the number of hospitalized people increased annually, and the results of the assessment of kidney function showed a decreasing trend.
25 , 27 , 47 One study involving 83 patients with activating EGFR mutations showed that patients with an increasing trend for T790M quantity from pretreatment to posttreatment of EGFR-TKIs had superior PFS and OS, compared to patients with a decreasing trend of T790M quantity. 44 , 48 Thanks to recent advances in the era of third-generation EGFR-TKIs such as osimertinib, it is better understood that patients with acquired T790M mutation will benefit more from osimertinib treatment than patients without T790M mutation.
18 Investigation of intravenous drug using in studies has shown a decreasing trend of the rate in recent years such that this amount has fallen from 37.0% in 2001 based on Khani and Vakili 24 to 6.5% in 2006 based on Hosseini et al. 16 This reduction can be attributed strategies such as harm reduction, greater coverage with methadone maintenance therapy, increased knowledge level in society and a better-informed media.