Barely Significant
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“an increasing trend”

63,972 sentences · 63,972 papers · 107,686 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

6 , 7 Consequently, tendinopathies impair daily activities and diminish quality of life, imposing substantial socioeconomic burden exciding EUR 180 billion in the USA and EU, with an increasing trend. 6 For many years, the prevailing paradigm in the field of tendinopathy has been that inflammation is the primary aspect to be tackled, leading to research focused on developing drugs to resolve inflammation. 8 , 9 Hence, the most commonly utilized therapeutics in the clinic for the management of tendinopathy include corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs).
Heatmap analysis of differentially abundant metabolites involved in pathways revealed significant reductions in 4-hydroxyphenylpyruvic acid, 1-methylhistamine, homogentisic acid, and formiminoglutamic acid when the UNx + HPD group was compared with the sham group; conversely, an increasing trend was observed in L-phenylalanine, urocanic acid, L-aspartic acid, normetanephrine, 3,4-dihydroxymandelate, vanillymandelic, and dopamine5,6-dihydroxyindol ( Figure 4D ).