“highly significant”

Aspartate aminotransferase (AST) levels demonstrated a highly significant group effect (F(5, 42) = 20.041, p < 0.001), with a very large effect size (η 2 = 0.705).

Results indicated that the activities of all antioxidant enzymes and their corresponding transcripts underwent highly significant decreases and downregulation in EcV-treated cultures (0.5 μg/ml medium for 4 h) compared to venom-free controls (P<0.001).

The Generalized Additive Model (GAM) revealed a highly significant non-linear trend in DUR across seasons (edf = 7.85, F = 11.55, p < 0.001), explaining 72.7% of the data deviance ( Figure 4 a).

The autoregressive coefficients (ar.L1 to ar.L4) were all highly significant ( p < 0.001), suggesting strong temporal dependencies in the CCL5 expression levels.

A repeated measures ANOVA revealed a highly significant main effect of stiffness on the applied assistive force (F(3,12) = 50.21, p < 0.001, partial η 2 = 0.93).

* p < 0.05 was considered significant, ** p < 0.01 was considered highly significant, and *** p < 0.001 was considered extremely significant.

These results were highly significant (P < 0.001) for all comparative parameters examined (HD, MSD, and RMSD).

In contrast, classical liver function markers showed highly significant differences: albumin was markedly reduced in class C (2.50 [2.40–2.70] g/dL vs. 3.20 [2.80–3.40] g/dL, p < 0.001), while INR was significantly increased (1.70 [1.50–1.80] vs. 1.30 [1.20–1.40], p < 0.001).

In RS and iCPO patients with FD, a highly significant association was found in CP grade between the two groups ( p < 0.001); while a grade 3 and 4 CP was most common in RS patients with FD (grade 3 = 60 %, n = 37; grade 4 = 23 %, n = 14), a grade 2 CP was most common in iCPO patients with FD (50 %; n = 19; Table 4 ).

Both the Begg and Mazumbar’s test and the Egger’s test resulted in highly significant indicators of publication bias ( P < 0.001).

Similarly, SOD activity showed highly significant differences between groups, both in GCF (F = 15.66, p < 0.001, η 2 p = 0.177) and in plasma (F = 20.94, p < 0.001, η 2 p = 0.223).

Similarly, NMN (100 μM) treatment exhibited the most pronounced reduction in p16 expression among all groups, with a highly significant inhibition ( p < 0.001).

In MCF7 cells, the combined treatment effect was slight at 500 nM doxorubicin ( P = .082), and highly significant at 1500 nM doxorubicin ( P < .001).

In the second analysis ( n = 39), comparison between group 1 and group 3 showed a highly significant difference (U = 36.00, Z = −3.96, p < 0.001), also surviving Bonferroni correction.

MANOVA revealed highly significant ( p < 0.001) differences between all populations in raw data as well as in size-corrected data.

Separate analyses showed that this occurred because the interaction was highly significant for cavity-nesting species ( t 34 = −3.659, P < 0.001), significant for ground-nesting species ( t 22 = −2.376, P = 0.016) and non-significant for branch nesting species ( t 75 = −0.838, P = 0.253).

A highly significant model ( R 2 = 63.2%, P < 0.001) was obtained with three variables: year ( b = 0.61 ± 0.12, P < 0.001), June mean temperature ( b = 3.71 ± 1.13 P = 0.002), and first inspection of hives ( b = −0.21 ± 0.09, P = 0.028).

A/Dar infection resulted in a highly significant increase across all three fractions ( p < 0.001 to p < 0.0001), particularly in the 17K fraction.

p < 0.05, *, indicates significant difference; p < 0.01, **, indicates highly significant difference; p < 0.001, ***, indicates extremely significant difference; p > 0.05, ns, indicates no significant difference. 2.7.

After censoring non disease-related deaths of patients, the disease-free survival was highly significant ( p < 0.001) (Fig. 3 ).

At the regional scale, highly significant differences were observed ( p < 0.001) ( Figure 4 ).

All pairwise contrasts were highly significant ( p < 0.001), underscoring the strong temporal association between vaccine rollout and reduced mortality ( Table 1 ; Figure S2B ).

At r = 0.81 the agreement between sABI and aABI was highly significant ( P < .001).

Based on the conducted Two‐Way Repeated Measures ANOVA, the proportion of pectins in the neck cell wall (NCW) statistically differed from that in the stalk cell wall (SCW), which is supported by a highly significant dependency of the enzymatic hydrolysis effect on the cell position ( p < 0.001).

Enteral feeds commenced earlier in infants of the TAT group (median POD# 3) compared to the NOTAT group (median POD# 13), a difference that was highly significant ( p = 0.001).