“highly significant”

This difference was highly significant ( P < 0.001).

Given these rigorous metrics alongside highly significant factor loadings ( p < 0.001), the convergent validity and internal reliability of the developed scale are conclusively verified.

Differences for confirmed KP were highly significant ( p < 0.001).

Statistical analysis revealed highly significant differences between bankrupt and healthy companies across multiple financial dimensions ( p < 0.001 across all key features), with effect sizes reaching Cohen’s d = 0.307 for company size.

Drug ATC was highly significant in the univariate analysis (logistic regression model without random effects: p < 0.001).

BDNF had the best results with a highly significant increased neuron survival in comparison to the negative control (45.7% ± 12.6% versus 10.7% ± 4.2%; P < 0.001), as well as compared to all other experimental groups ( P < 0.001).

Noteworthy, we observed a highly significant inverse correlation between retinal arteriolar flicker response and ADMA levels (r = -0.531, p=0.001).

The main effect of block was highly significant on both Day 1 ( F 5,140 = 7.56, p < 0.001) and Day 2 ( F 5,140 = 6.57, p < 0.001), indicating that, as expected, freezing decreased across extinction trials.

Additionally, the association between migraine-attributed disability and lost household work time or total lost productivity (paid + household) was highly significant ( p < 0.001) in almost all countries studied.

Pairwise comparisons of mean values were conducted using Tukey’s Honest Significant Difference (HSD) post-hoc test specifically for solution type, nozzle size, and operating pressure, as these factors exhibited highly significant differences ( p < 0.001).

The negbin variant of count models was used as the estimated alpha parameters were greater than zero (0.185; 0.075) and highly significant ( p < 0.001; p = 0.003), and both dependent variables had a low number of zero observations.

However, when the LNR with a cutoff value of 0.2 was included as a covariate in the model, the LNR was highly significant (p<0.001), and the pN stage lost its significance (p>0.05).

Presence of EF Anterior EF was observed in 123 (95.3%) of the patients with isthmic spondylolisthesis cases but in only 41 (28.3%) of those with degenerative spondylolisthesis; this difference was highly significant ( p <0.001).

4b ) revealed a highly significant difference in cell recovery between the two groups (Mann–Whitney U test, p < 0.001).

Similarly, computing non‐linear generalized additive mixed models across all cfDNA values, cfDNA concentrations increased non‐linearly with energy expenditure, as indicated by highly significant smooth terms for both sexes ( F = 35–44, p < 0.001) and high overall model fits (adjusted R 2 = 0.87–0.88).

There was a highly significant interaction between Run Length and Reference bp ( F 5, 8865 = 11.02, P < 0.001; fig. 1 A ).

The differences were highly significant at each interval (baseline: Z = −4.113, P < 0.001; 6 months: Z = −7.337, P < 0.001; 1 year: Z = −8.576, P < 0.001; 2 years: Z = −7.035, P < 0.001).

20 We cannot discriminate between the relative impact of epilepsy per se, seizures or ASD therapy on cerebellar dysfunction and atrophy, but the association of cerebellar atrophy and the calculated lifetime drug load of the four most frequent ASDs (carbamazepine, diphenylhydantoin, phenobarbital, and valproate) was highly significant ( p < .001).

As shown in Supplementary Table S4, both RPKM and copy number remained highly significant predictors ( p < 0.001) after accounting for intra-center correlation, confirming that our nomogram models are robust to variations between centers.

The analysis imputed 8 missing studies, but the adjusted pooled effect size remained highly significant (OR = 0.745, 95% CI : 0.677 to 0.819, p < 0.001).

The aGAPSS emerged as a highly significant independent predictor (OR 1.053; 95% CI 1.031 to 1.076; p<0.001), indicating that each unit increase in the score corresponds to a 5.3% increase in the odds of a positive diagnosis.

Results: Multivariate analysis shows that adjuvant-treated stage III or high-risk stage II patients experienced a highly significant increase in OS (hazard ratio [HR]: 0.34, 95% confidence interval [CI]: 0.20–0.59, P <0.001) and CSS (HR: 0.39, 95% CI: 0.20–0.75, P = 0.005) compared with the control group without adjuvant chemotherapy.

4 , 7 In our cohort, we observed a moderate but highly significant correlation between LVEF and GLS (ρ = 0.47; P <.001), consistent with previously reported moderate-to-strong linear relationships. 7 , 8 , 9 A multivariable Cox proportional hazards model was used to identify independent factors of OS ( Table 2 ).

The model was highly significant ( F (1,1710) = 7219.36, p < 0.001) and demonstrated a strong association with genome editing acceptability (R 2 = 0.808, Adjusted R 2 = 0.808).

The severity of deformity demonstrated a highly significant independent predictive value (HR = 0.459, P < 0.001).