“highly significant”

As expected from the definition of the 0.1% threshold, it was highly significant to discriminate PFS between both groups of patients (Figure 3 , p = 0.0017) and although OS was better for the HFLC‐low group, the difference was not statistically significant.

Three and four month in-situ explants had highly significant differences in failure load between measurements close and distant to the osteotomy line: p=0.0017 (the region of maximum load in-situ ).

Moreover, 68 PSGs were both down-regulated in the long-lived naked mole-rat and up-regulated in the short-lived rat during aging ( Fig 2 ), resulting in a highly significant preference for quadrant I (down in naked mole-rat, up in rat; p = 0.0017, one-sided fisher test, quadrant I against the sum of II, III, IV).

A linear correlation was highly significant between the measurements of conidial hydrophobicity and adherence from the tested strains (r 2 = 0.975, F 1,19 = 116.7, p < 0.0017).

The similarly sized (.354 ≤ r ≤ .460) and highly significant (.00003 ≤ p ≤ .00171) correlations suggest that all automated approaches produced scores that were good approximations of the manual codes.

We were able to demonstrate a highly significant difference ( p = 0.00175).

As shown in Table 3 , the model was highly significant for the experimental results with a 95 % confidence level (p-value = 0.0018).

When survival data from both Hep3B and SNU-449 models were combined ( Figure 5 H), the Mantel-Cox log rank test generated a highly significant difference between LV-treated and control groups (p = 0.0018).

Subgroup analysis In the subgroup analysis of patients who had received first-line treatment according to the TKI strategy, the PFS still exhibited a highly significant difference between the two groups (P=0.0018) ( Figure 4 ): the mPFS was 4.0 months (95% CI, 3.6–6.8 months) in the regorafenib group and 10.0 months (95% CI, 7.2–32.4 months) in the combination group.

In particular, the enrichment of the ZRS in comparison to flanking non-ZRS regions is highly significant (amplicons “b” to “d” versus “a” and “e”; p = 0.0018), while the variability among the three ZRS amplicons is not significantly different.

These differences were highly significant (0.0001 < P < 0.0018) in the C57BL/6, 129S6 and BALB/c backgrounds, but less so in the CBA/Ca background (0.017 < P < 0.048), and not significant for the specific comparison of the CBA/Ca homozygotes at 32 and 16 kHz ( P = 0.11).

A study of the benefit of HSCT showed that the difference in mean overall survival time between those who underwent transplantation (9 allogeneic [allo], 1 autologous) and those who did not was highly significant (31.3 vs 12.8 months; P = .0018). 4 Less information is available on the optimal therapeutic approach to LS-BPDCN specifically.

The regression analysis, using λ as the dependent variable and only the guanaco population size (in natural logs, LnNtot ) as the independent variable, was highly significant (AIC = -87.847, p < 0.0018, and F = 11.48,) and the resulting regression equation was λ = 1.6373 – 0.0552 (±0.0163) Ln Ntot ( Table 2 ).

Body mass showed highly significant ( p = 0.0018) differences depending on spine type and in post-hoc analyses, a significant difference ( p = 0.0230) concerned the comparison of the groups “decreased kyphosis and increased lordosis” and “increased kyphosis and increased lordosis”.

When entering the delta change of SII (hospital admission-discharge) in the GLM model, with length of hospital stay as nuisance covariate, delta SII showed a significant effect (higher reduction of SII, lower depression; F = 4.24, p = 0.0438) and the time x treatment interaction remained highly significant (F = 7.07, p = 0.0018).

More importantly, the slope of the concentration-effect line was steeper for the thalamus than for the cortex for all frequency bands and the differences were highly significant (p < 0.0018 for the 126–200 Hz range; p < 0.0001 for the other bands.

This was highly significant for DHEAS (20 vs. 48 weeks, P = 0.0018) with less significant trends noted for DHEA, T, and ASD ( P = 0.13, 0.041, and 0.049 respectively; Fig. 4D ).

In addition, mean differences between the three rank groups were highly significant for blue-red contrast residuals (Kruskal-Wallis χ 2 = 12.5, p = 0.0018) while being not significant for blue saturation residuals (KW χ 2 = 5.68, p = 0.058) and for red saturation residuals (Kruskal-Wallis χ 2 = 5.45, p = 0.065), although both are close to significance.

The difference between the two treatments in the cortex was highly significant ( p = 0.0018).

Kaplan–Meyer curves analyzing tumor engraftment in function of the time from injection, followed by Log-rank (Mantell–Cox test), showed a highly significant difference between FRTL5-Ras-PATZ1-injected mice and their controls ( P = 0.0018; HR = 0.1914; 95% CI 0.01456-0.2701) ( Figure 1 a).

In the higher dose iron and curcumin group (F65_Curc), there was a highly significant reduction in plasma TNF levels (0.65 pg/mL ± 0.17, p = 0.0018) when comparing mid-point mean levels to end-point mean levels ( Figure 3 ).

If two genes have a correlation larger than this threshold, 0.80, this correlation is highly significant ( P < 0.0018) based on the Fisher transformation test.

However, we found a highly significant correlation ( P = 0.0018) for proteins classified in Pfam-A ( Figure 3 ).

Despite their relative infrequency (dozens per 24‐h period), fast ripples achieved highly significant group discrimination ( p = 0.0018), demonstrating sufficient statistical power for biomarker utility.

This region shows highly significant evidence of LD variation between Chinese, European (Monte Carlo [MC] p = 0.0018), and African (MC p = 0.0003) individuals, but nominal evidence of variations between Chinese and Japanese (MC p = 0.0107) (ESM Table 12 and ESM Figs 7 and 8 ).