“highly significant”

The differences were highly significant ( p < 0.00001) for both a 2 h treatment and an overnight treatment, suggesting that if we had used the earlier material in the second trial it could have proved more effective.

Correlation analysis showed a highly significant linear positive relationship (R 2 = 0.466; p < 0.00001) of plasmatic B4GALTs with age from infancy to centenarians (Figure 1A ).

To lend further support to the relationship between hepatic inflammation and TG levels in the liver, there were highly significant positive correlations between hepatic TG levels and TNFα (P < 0.00001), MCP1 (P = 0.0001), IL6 (P < 0.001) and IL1β (P < 0.00001) protein levels.

Figure 7 a shows the relationship between LAI r and LAI-vc e by applying method (ii) with k r obtained by inverting Equation (7), which rendered highly significant statistical analysis ( Table 4 ) as expected ( R 2 = 0.94; b = 0.98; SEE = 0.71; RMSE = 0.15; p < 0.00001).

This trend is highly significant ( p < 1 × 10 −5 ; two-sided permutation test).

Similarly, the liraglutide versus placebo/standard treatment subgroup (Figure 4 ) showed a highly significant reduction in BMI (MD: −1.75 kg/m2; 95% CI: −2.38 to −1.12; p < 0.00001), again with no heterogeneity (I2 = 0%), reinforcing the reliability of liraglutide’s effect in weight reduction.

As expected, different subphyla harbor very different sets of TEs, as revealed by a highly significant interaction between taxonomic group and TE family ( F 38,1103 = 7.43, P < 0.00001).

The first ranked ChIP-seq track found is the one against an overexpressed haemagglutinin (HA)-tagged MITF 21 , indicating a highly significant correlation between the E-box/MITF predictions and the ChIP-seq data (hypergeometric adjusted P -value<1.0e−05, Normalized Enrichment Score=31.2).

Despite this heterogeneity, the overall effect size is highly significant ( Z = 30.91, p < .00001).

The difference in attitude between MBBS and nursing students was statistically highly significant ( P = 0.00001), whereas the levels of knowledge ( P = 0.1359) and practice ( P = 0.9297) were not statistically significant ( P > 0.05).

The test for overall effect was highly significant (Z = 8.34, P < 0.00001).

The differences were highly significant for both Fusobacterium and Porphyromonas (FDR-adjusted p -value < 0.00001, Fisher Exact test).

High IL-2 levels, IFN-γ levels, CD4 subset, and CD4/CD8 ratio, and low IL-10 levels and CD8 subset in HS were highly significant ( P <0.00001–0.005).

After adjusting for sex, age, and race/ethnicity in Model I, the negative association remained highly significant (β = −0.038, 95% CI: −0.045 to −0.031, p < 0.00001).

This dichotomy between the effects of HP1E depletion on the euchromatic and heterochromatic compartment is highly significant (p < 0.00001) and suggests a direct action of HP1E in the heterochromatic compartment, akin to its closest HP1 relative, HP1A ( Kellum et al., 1995 ; Levine et al., 2012 ).

In adjusted multivariate analysis, the only factor that was significantly associated with chromosome 3p loss was having a VHL gene alteration, and the association was highly significant (OR = 1250; 95% CI:476–3125, p<0.00001).

In terms of tumor size, margin positivity increased with tumor size: 37.5% for T1 tumors, 24.09% for T2 and 64.81% for T3 tumors, with a highly significant association ( p < 0.00001) (Table 7 ).

Phenotypic correlation Highly significant correlations were found between dormancy and GA 3 content in tubers ( P <0.00001).

However, since there are only around 80 confirmed and 120 predicted imprinted loci in total in the human genome, the observation of even just ten of these genes in our study represents a highly significant enrichment ( P < 1 × 10 −5 ; permutation test).

Four of the 142 sequenced genotypes were identified as outliers along four different and highly significant axes of variation ( P < 10 −5 from tests based on the Tracy–Widom distribution) based on the default settings of the smartpca program within the EIGENSOFT package ( Patterson et al. , 2006 ).

This effect size is also highly significant at a level of 0.01 ( P < 0.00001).

This was highly significant with a P = 0.00001.

The overall effect test is highly significant, with a Z value of 4.69 ( P < .00001).

This revealed a total of 52 out of 176 neurofeedback runs that achieved high regulation (~30%; median per participant: 2; MAD: 1.7; range: 0–6), which was highly significant according to binomial testing ( P < 0.00001) (Fig. 2C ).

A highly significant ( p ≤ 0.00001) reduction of E‐cadherin expression was observed in the order of HPV16+ < HPV18+ < HPV16+/18+ in both cell models.