“highly significant”

When test and training data were from the same day, estimates of mouse location were excellent (median error nearly always <7 cm) and highly significant compared to shuffled test data ( P <10 -160 ; Kolmogorov-Smirnov test).

In the subgroup comparison between the high LDL-C and CAD subgroups, a highly significant difference was observed for LDL-C ( P = 5.8×10 -158 ) because the high LDL-C subgroup was originally defined using LDL-C levels.

The extent of overlap was highly significant ( p = 1.32E-157 and p = 2.09E-200 for genes associated with COO-unclassified DLBCL or COO class, respectively).

We also note that due to the statistical power of the study some highly significant associations may not be as clinically impactful due to small effects sizes (e.g., age with OR = 1.01; p = 2.61 × 10 − 157 for survey question 1).

There was a very highly significant ANOVA [ F (95, 408) = 40.34, p = 3.689e −157 ].

For OtV-type 2a, Ka​/Ks ratios were consistently >1 across all models, with highly significant P -values (average of ω = 1.3 and a P -value = 3e-155), indicating strong diversifying (positive) selection.

Using the same Mann–Whitney U test, we find a corrected p -value to be highly significant when comparing LD-18 and HD-18 samples ( p -value = 4.78–153).

In particular, 22 and 17 elements were detected for microRNAs 128 and 138 MREs, respectively, with a highly significant enrichment ( P < 1E −150 , Supplementary Figure 3 and Supplementary Table 3 ).

Interestingly, this trend is highly significant ( P < 10 -150 ) for all event lengths except for 3 bp, showing that degenerate codon positions evolved to reduce the indel propensity of frame shifting indels more than frame conserving mutations.

For five quantitative traits (BMI, DBP, FEV, RHR, and SBP), per-standard deviation (perSD) Beta values for rvPRS showed highly significant associations (max P = 1.21E-149; significance threshold P < 1.26E-04 = 0.05/18/22).

\usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\bar{w}\left({n}_{{wt}}\right)=$$\end{document} w ̄ n w t = 0.48, a difference that is highly significant ( P = 3.8 × 10 −148 , two-sided Mann–Whitney U = 43,750, n = 681).

The precision of this alignment was further quantified, showing a 74.5% overlap between high-risk and tumor cell categories, with McNemar’s test 84 demonstrating a highly significant association ( P = 3.54 × 10 −146 ) (Fig. 5 d), thereby supporting SIDISH’s accuracy in identifying cellular drivers of poor prognosis within their spatial context.

Furthermore, Wilcoxon signed‐rank tests comparing the absolute prediction errors of RINAMI and the baseline model showed highly significant performance differences across the three Mega‐scale test subdatasets, with p ‐values below 0.01 in all splits ( p = 5.95 × 10 −145 , p < 1.00 × 10 −300 , and p = 1.39 × 10 −25 ).

Although the sublamination of the IPL was clearly less organized than in the WT, in this very thin IPL-like neuropil the typical apical/basal pattern was still obvious ( Figures 2 G and 2I) and highly significant (p = 3.0 × 10 −144 ; Figure 2 J).

Another highly significant feature ( p = 5.1 × 10 −144 ) was the number of upstream AUGs.

5 G) included 773 genes, which is highly significant ( p = 8.5 × 10− 142 ) with a strong odds ratio of 10.27, indicating that the overlap is about 10 times more frequent than would occur by chance.

In particular, the fluorescence intensity of SUVs preferred by 15GALA-NP increased approximately 2 orders of magnitude compared to free GALA, showing highly significant skewness ( p = 1.12 –141) by comparing the two distributions in a two-sided Welch’s t -test.

The APOE genetic signal remained highly significant in an age-stratified GWAS, on participants with age 60 years or more (OR 1.7, 95% CI 1.63–1.77; P = 2.7 × 10 −141 ; Extended Data Fig. 6 and Supplementary Table 2 ).

Of these, 140 SNPs indexed differences in HDL- and LDL-cholesterol, triglycerides, C-reactive protein, fibrinogen, factor VII, apolipoproteins AI and B, lipoprotein-associated phospholipase A2, homocysteine or folate, some with large effect sizes and highly significant P -values (e.g. 2.15 standard deviations at P = 9.2 × 10 −140 for F7 rs6046 and FVII levels).

The Steiger analysis demonstrated highly significant directional associations for CEP68 using both blood ( p = 1.92 × 10 −137 ) and LAA ( p = 4.88 × 10 −49 ) eQTLs.

This overlap is highly significant by factor of over-representation (4) and P -value ( P < 3.1 e-136).

Genetic analyses uncovered a missense change, c.1288G>A; p.A430T, in the autophagy-related ATG4D gene on canine chromosome 20 with a highly significant disease association (p = 3.8 x 10 -136 ) in a cohort of more than 2300 Lagotto Romagnolo dogs.

Comparison of F ST values on chromosome 1 between PK10 and Thailand were highly significant (pairwise- t = 26.9, d.f. = 1934, p -value = 1.15 × 10 −135 ), and PK10 F ST values were greater than Thailand F ST values in 1387 of the 1935 genes compared (71.6%).

Figure 7B shows there was a highly significant overlap between the genes affected by cordycepin in the two cell lines ( P < 1.44 × 10 −135 by one‐tailed Fisher's exact test).

Furthermore, the Z-score-based meta-analysis of 1,239 animals in the exploratory cohort revealed a highly significant negative correlation between pH and lactate levels at the individual animal level ( r =–0.62, P =7.54 × 10 –135 ; Figure 1B ).